Yes, 100% pure silver is a Kryptonite of sorts for vampires just as it is for werewolves. A pure 100% silver bullet or silver stake to the heart will cause instant death. Hitting them elsewhere will cause prolonged agony before their eventual death. However, if they can remove the silver from their body in time they can recover. Silver has a negative effect on a variety of paranormal beings with demonic DNA due to its ancient roots as a curative for various ailments. Just as all things demonic have been a plague on humankind from day one! The most common form of use in human maladies is colloidal silver. When injected with enough colloidal silver a vampire will get very sick and die. Silver essentially kills the demonic vampire virus that infects every vamp who was a former human. Natural born first-generation royal vampires have true demonic DNA while also carrying the virus so they can turn humans into their own kind. Unfortunately killing off the virus doesn’t revert the subject back to human form but rather a pile of ash!
Absolute pure silver is required or it will only make them sick, and they’ll recover. This is unlike Werewolves who are very sensitive to any amount of silver and can die from a silver-plated bullet hitting them anywhere. In addition, werewolves are going to die even if they remove the silver bullet rather quickly. Another important fact is that merely possessing silver will not repel a vampire as it does with werewolves who get deep negative energy vibes from the metal. Making contact with silver on a vampire’s skin will only cause minor burns. You can also take two bars of silver to form a cross which would repel a vampire with a bit more authority than a wooden cross.